购物车
- 全部删除
- 您的购物车当前为空
Flavokawain C 是存在卡瓦胡椒根中的一种天然查尔酮,具有发展成为治疗结肠腺癌的化疗药物的潜力。它对 HCT 116 细胞作用的 IC50值为 12.75 μM。
Flavokawain C 是存在卡瓦胡椒根中的一种天然查尔酮,具有发展成为治疗结肠腺癌的化疗药物的潜力。它对 HCT 116 细胞作用的 IC50值为 12.75 μM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 283 | 现货 | |
2 mg | ¥ 395 | 现货 | |
5 mg | ¥ 662 | 现货 | |
10 mg | ¥ 1,060 | 现货 | |
25 mg | ¥ 1,930 | 现货 | |
50 mg | ¥ 2,870 | 现货 | |
100 mg | ¥ 4,170 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 762 | 现货 |
产品描述 | Flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava.FKC has the potential to be developed into chemotherapeutic drug for the treatment of colon adenocarcinoma. |
体外活性 | Flavokawain C(FKC)显著降低了HT-29细胞的活性,并导致细胞和核形态发生剧烈变化,出现典型的凋亡特征。凋亡的诱导与磷脂酰丝氨酸的外翻、DNA断裂、线粒体膜电位下降、caspases激活和PARP裂解密切相关。与此同时,活性氧物质增加,SOD活性下降。XIAP、c-IAP1和c-IAP2的蛋白水平下调,而GADD153在FKC处理后上调。FKC通过上调p21和p27在p53独立的方式中诱导细胞周期在G1和G2/M阶段停滞。FKC具有发展成为治疗结肠腺癌化疗化合物的潜力[1]。 |
细胞实验 | Cell viability of HT-29 cells was assessed by Sulforhodamine B assay after FKC treatment.?Induction of apoptosis was examined by established morphological and biochemical assays.?ROS generation was determined by dichlorofluorescein fluorescence staining, and superoxide dismutase activity was measured using the spectrophotometric method.?Western blotting was used to examine the changes in the protein levels[1]. |
别名 | 黄卡瓦胡椒素 C, 卡瓦胡椒素C |
分子量 | 300.31 |
分子式 | C17H16O5 |
CAS No. | 37308-75-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 25 mg/mL (83.25 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
|
版权所有©2015-2024 TargetMol Chemicals Inc.保留所有权利.